Independent · non-commercial · publishes on a quarterly cycle|Current cycle 2026 Q3
Compound Evidence InstituteEvidence synthesis · established 2023Graded assessments of compounds, trials, methods and supply
Document set current to 30 July 2026
Consultation record

Submissions accepted in part — page 13

Part of the submission is accepted and part is not. The secretariat response states which part is which and on what ground the remainder was declined.

Submissions

390 documents · page 13 of 13

Table 1. Submissions with this disposition, on this page.

ReferenceConsultationRespondentPoint raised
DRAFT-SPONSOR-COND/001Draft synthesis: The consequences of a wholly sponsor-generated…Dr Yaa KettlewellPoint estimates are given without an interval
DRAFT-SPONSOR-COND/007Draft synthesis: The consequences of a wholly sponsor-generated…Thaddeus Isaksen-BalogunThe choice of effect measure is not justified and changes the appearance of the result
DRAFT-SPONSOR-COND/008Draft synthesis: The consequences of a wholly sponsor-generated…Dr Kolawole Isaksen-BalogunThe axis of the forest plot exaggerates a small difference
DRAFT-SPONSOR-COND/010Draft synthesis: The consequences of a wholly sponsor-generated…Dr Adaeze Underhill-OkaforTwo included studies do not meet the registered eligibility criteria
DRAFT-SURROGATE-OU/001Draft synthesis: Percentage weight change as a surrogate outcomeDr Adaeze Underhill-OkaforTwo included studies do not meet the registered eligibility criteria
DRAFT-SURROGATE-OU/002Draft synthesis: Percentage weight change as a surrogate outcomeDr Matthias Wintringham industryA sponsor trial meeting the eligibility criteria was excluded
DRAFT-SURROGATE-OU/006Draft synthesis: Percentage weight change as a surrogate outcomeThaddeus Isaksen-BalogunCrossover trials are pooled with parallel-group trials without adjustment
DRAFT-AMYLIN-ANALO/005Draft synthesis: Amylin analogues as monotherapy and in combinationDr Matthias Wintringham industryA sponsor trial meeting the eligibility criteria was excluded
DRAFT-AMYLIN-ANALO/006Draft synthesis: Amylin analogues as monotherapy and in combinationProfessor Bartolomeu Nkosi-LindegaardRegulatory assessment documents were not searched
DRAFT-RECONSTITUTI/004Draft synthesis: Reconstitution practice and delivered doseDr Oisín RautavaaraMultiple vials from one lot are counted as independent observations
DRAFT-RECONSTITUTI/005Draft synthesis: Reconstitution practice and delivered doseDr Jolyon Grünbaum-SowandeWhat the contributing methods could not have detected is not stated
DRAFT-RECONSTITUTI/007Draft synthesis: Reconstitution practice and delivered doseAnselm MountstephenThe review protocol is described but its registration record is not linked
DRAFT-RECONSTITUTI/009Draft synthesis: Reconstitution practice and delivered doseDr Vittoria QuintanilhaThe search was limited by publication date and the limit is not justified
DRAFT-PANCREATITIS/002Draft synthesis: Acute pancreatitis with incretin-based therapiesDr Emiliana OllerenshawStudies not published in English were excluded without assessment
DRAFT-PANCREATITIS/007Draft synthesis: Acute pancreatitis with incretin-based therapiesDr Adaeze Underhill-OkaforTwo included studies do not meet the registered eligibility criteria
DRAFT-PANCREATITIS/008Draft synthesis: Acute pancreatitis with incretin-based therapiesDr Vasilisa ImmelmannRegulatory assessment documents were not searched
DRAFT-PANCREATITIS/009Draft synthesis: Acute pancreatitis with incretin-based therapiesEamon Sandringham-AduReferences should carry a persistent identifier for every cited source
DRAFT-ENDOTOXIN-IN/002Draft synthesis: Bacterial endotoxin in research-supply peptide…Professor Bartolomeu Nkosi-LindegaardRegulatory assessment documents were not searched
DRAFT-PRIMARY-VS-S/003Draft synthesis: Cardiovascular benefit in primary compared with…Dr Yaa KettlewellThe axis of the forest plot exaggerates a small difference
DRAFT-PRIMARY-VS-S/004Draft synthesis: Cardiovascular benefit in primary compared with…Dr Adaeze Underhill-OkaforTwo included studies do not meet the registered eligibility criteria
DRAFT-PRIMARY-VS-S/008Draft synthesis: Cardiovascular benefit in primary compared with…Dr Kolawole Isaksen-BalogunStatistical heterogeneity is treated as though it measured clinical heterogeneity
DRAFT-TIRZEPATIDE-/006Draft synthesis: Tirzepatide compared with semaglutide in type 2…Dr Odalys Thorsby-NakamuraTwo included studies do not meet the registered eligibility criteria
DRAFT-TIRZEPATIDE-/007Draft synthesis: Tirzepatide compared with semaglutide in type 2…Dr Kolawole Isaksen-BalogunSubgroup findings are reported that were not registered in the protocol
DRAFT-PEPTIDE-PURI/001Draft synthesis: Dependence of reported purity on the analytical…Eamon Sandringham-AduThe review protocol is described but its registration record is not linked
DRAFT-PEPTIDE-PURI/003Draft synthesis: Dependence of reported purity on the analytical…Thaddeus Isaksen-BalogunMultiple vials from one lot are counted as independent observations
DRAFT-PEPTIDE-PURI/004Draft synthesis: Dependence of reported purity on the analytical…Professor Bartolomeu Nkosi-LindegaardRegulatory assessment documents were not searched
DRAFT-MITOCHONDRIA/001Draft synthesis: Mitochondria-targeted peptides in bioenergetic…Dr Oisín RautavaaraCrossover trials are pooled with parallel-group trials without adjustment
DRAFT-MITOCHONDRIA/002Draft synthesis: Mitochondria-targeted peptides in bioenergetic…Ms Rhiannon Okoye-VandergraafPatient-reported outcomes are collected by the trials and not reported by the review
DRAFT-MITOCHONDRIA/003Draft synthesis: Mitochondria-targeted peptides in bioenergetic…Anselm MountstephenThe review protocol is described but its registration record is not linked
DRAFT-MITOCHONDRIA/006Draft synthesis: Mitochondria-targeted peptides in bioenergetic…Professor Bartolomeu Nkosi-LindegaardRegulatory assessment documents were not searched

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