Public comment period · §3
Draft synthesis: Human evidence for BPC-157 — disposition
The disposition of every submission and the amendments that resulted.
§3Disposition and amendments
§3.1Disposition table
Table 1. Every submission with its disposition. Each row links to the submission in full.
| Reference | Respondent | Point raised | Disposition |
|---|---|---|---|
| DRAFT-BPC-157-HUMA/001 | Dr Oisín Rautavaara | A funnel plot is presented for a set too small to interpret it | Accepted |
| DRAFT-BPC-157-HUMA/002 | Ms Rhiannon Okoye-Vandergraaf | Patient-reported outcomes are collected by the trials and not reported by the review | Accepted in part |
| DRAFT-BPC-157-HUMA/003 | Dr Matthias Wintringham industry | A sponsor trial meeting the eligibility criteria was excluded | Accepted in part |
| DRAFT-BPC-157-HUMA/004 | Professor Bartolomeu Nkosi-Lindegaard | Regulatory assessment documents were not searched | Accepted in part |
| 4 submissions in total. | |||
§3.2Summary by disposition
Table 2. Counts by disposition, with the meaning of each.
| Disposition | Count | Meaning |
|---|---|---|
| Accepted | 1 | The submission is accepted and the draft is amended as proposed. The amendment is recorded in the amendment log of the document it changed and is traceable to the numbered submission. |
| Accepted in part | 3 | Part of the submission is accepted and part is not. The secretariat response states which part is which and on what ground the remainder was declined. |
| Noted, no amendment | 0 | The submission raises a point the Institute accepts but that does not require a change to the draft, most often because the draft already states it elsewhere. The location is given in the response. |
| Not accepted | 0 | The submission is not accepted. The secretariat response gives the reason. A submission that is not accepted remains published in full; the Institute does not remove a submission because it disagrees with it. |
§3.3Resulting amendments
- A funnel plot is presented for a set too small to interpret it — arising from DRAFT-BPC-157-HUMA/001. The funnel plot is removed for every outcome contributed by fewer than ten studies, and replaced by a statement that small-study effects could not be assessed at that number, together with the count of registered trials identified without posted results.
- Patient-reported outcomes are collected by the trials and not reported by the review — arising from DRAFT-BPC-157-HUMA/002. Patient-reported outcomes measured by any contributing trial are now reported narratively by instrument, with the instrument named and its minimum important difference stated where one is published, and the absence of a pooled estimate explained.
- A sponsor trial meeting the eligibility criteria was excluded — arising from DRAFT-BPC-157-HUMA/003. The trial is added to the included set, the estimate and the certainty rating have been recomputed, and the screening record now states why the trial was missed, which was a database indexing gap rather than a screening judgement. The submission is identified…
- Regulatory assessment documents were not searched — arising from DRAFT-BPC-157-HUMA/004. Published regulatory assessment documents are now searched as a named source, are reported as a distinct evidence class in the included-studies table, and contribute to the assessment while being excluded from pooled estimates where risk of bias could not be…
References cited on this page
References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.
- International Organization for Standardization. ISO/IEC 17025:2017 General Requirements for the Competence of Testing and Calibration Laboratories. ISO/IEC Standard 2017;3rd edition. identifier not held by the Institute
Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.
Compound Evidence Institute · CEI-CP-107/3 · https://compoundevidence.com/comment-periods/draft-bpc-157-human-evidence-synthesis/disposition/ · retrieved 30 July 2026