IGF-1 LR3 in sarcopenia and lean-mass preservation during weight reduction — evidence extract
No eligible study has been identified for IGF-1 LR3 in sarcopenia and lean-mass preservation during weight reduction. The Institute records the question as not assessed and states what would change that.
§1Evidence extract: Sarcopenia and lean-mass preservation during weight reduction
§1.1Question and anchor outcome
- Population
- Loss of skeletal muscle mass and function, considered here principally as a consequence of rapid weight reduction under incretin therapy.
- Intervention
- IGF-1 LR3, subcutaneous in research contexts
- Comparator
- As used in each contributing trial; reported per trial rather than pooled across comparator types
- Anchor outcome
- Change in appendicular lean mass by DXA
Additional outcomes the Institute extracts for this indication: Change in fat-free mass by MRI; Grip strength; Physical performance battery.
§1.2Contributing trials
No trial has been identified for IGF-1 LR3 in sarcopenia and lean-mass preservation during weight reduction. No certainty rating is issued where that is so, for the reason given at §1.3.
§1.3Why no certainty rating is issued
The Institute rates certainty in a body of evidence. Where no eligible study has been identified there is no such body, and the domain-by-domain assessment used elsewhere in this series is not rendered: an inconsistency judgement requires two estimates to be inconsistent with one another, and an imprecision judgement requires an interval. Neither exists here.
The outcome is therefore recorded as not assessed. It is listed in the certainty index under that heading rather than at the lowest rating, because a rating of very low certainty says that evidence was found and is weak, and that is not what has happened.
What would change this: a controlled study in the population stated at §1.1, reporting the anchor outcome, retrievable in a form the Institute can appraise. The evidence gaps recorded in the monograph at §9 state what such a study would need to measure.
§1.4What this extract does not establish
References cited on this page
References are numbered in order of first citation in this document. Each superscript in the text links to its entry below.
- International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use. ICH Q6B Specifications: Test Procedures and Acceptance Criteria for Biotechnological/Biological Products. ICH Harmonised Tripartite Guideline 1999;Step 4 version. identifier not held by the Institute
- United States Pharmacopeial Convention. General Chapter ⟨85⟩ Bacterial Endotoxins Test. United States Pharmacopeia — National Formulary (USP–NF) 2024;USP 2024 Issue 1. identifier not held by the Institute
- International Organization for Standardization. ISO/IEC 17025:2017 General Requirements for the Competence of Testing and Calibration Laboratories. ISO/IEC Standard 2017;3rd edition. identifier not held by the Institute
Identifiers are reproduced only where the Institute holds them. Where a digital object identifier or PubMed identifier is not shown, the Institute has recorded the journal and year and has not constructed an identifier.